When it comes to fertility, hormone balance and energy, we often focus on things like nutrition, stress, sleep or hormone levels. While these are all important, there is another piece of the puzzle that deserves more attention: mitochondria.

Mitochondria are often referred to as the powerhouses of the cell because they produce ATP, the energy currency that powers almost every process in the body. However, their role extends far beyond energy production. Mitochondria are involved in hormone production, DNA repair, immune function, inflammation regulation, cell signalling and healthy ageing.

Because mitochondria are involved in so many essential functions, dysfunction has been linked to a wide range of health concerns including fertility challenges, recurrent miscarriage, endometriosis, chronic fatigue, depression, autism spectrum disorder and age-related hormonal decline.

From a naturopathic perspective, supporting mitochondrial health is often an important part of improving overall wellbeing. Healthy mitochondria help create the foundation for healthy cells, healthy hormones and healthy ageing.

Mitochondria and Fertility

Fertility is one of the areas where mitochondrial health is particularly important.

Mitochondria help regulate energy production within both egg and sperm cells, but they are also involved in DNA repair, hormone production and healthy embryonic development.

One of the hormones produced with the help of mitochondrial function is pregnenolone. Pregnenolone is often referred to as the “mother hormone” because it serves as the precursor for progesterone, oestrogen, testosterone and cortisol. When mitochondrial function is compromised, hormone production can also be affected.

Mitochondria are also involved in glucose metabolism and blood sugar regulation. This is particularly relevant because unstable blood sugar levels can influence fertility, ovulation, hormone production and overall reproductive health.

Perhaps one of the most fascinating aspects of mitochondrial biology is that babies inherit their mitochondria exclusively from their mother. This means mitochondrial health doesn’t just affect fertility today. It may also influence the health and fertility of future generations.

For this reason, mitochondrial support can be an important consideration in preconception care and natural fertility support.

Why Egg Cells Need So Many Mitochondria

Egg cells (oocytes) are remarkable. They contain anywhere from 100,000 to more than one million mitochondria, far more than almost any other cell in the body. This enormous energy reserve is needed to support egg maturation, fertilisation and the earliest stages of embryonic development.

As women age, mitochondrial function within the ovaries gradually declines. By the age of 40, it is estimated that almost one-third of the mitochondria within oocytes are no longer functioning efficiently. This decline is one of the reasons fertility naturally decreases with age.

When fertilisation occurs, the egg does more than simply receive genetic material from the sperm. If there is DNA damage within the sperm, the oocyte uses its own mitochondrial reserves to help repair that damage. This process is essential for creating a healthy embryo.

Because of these demands, egg quality is closely tied to mitochondrial health.

Why Sperm Health Matters

While sperm are tiny compared to an egg, they contribute half of the genetic material needed to create a baby. Male fertility is often prioritized less then female fertility, yet male factor issues contribute to around 50% of fertility challenges.

Unlike egg cells, sperm contain only a few dozen mitochondria. These mitochondria are located within the midpiece of the sperm and provide the energy required for movement.

At the moment of conception, the sperm penetrates the egg and delivers its DNA into the oocyte. The sperm mitochondria themselves are not inherited by the baby. Instead, the egg uses its own mitochondrial resources to support early development and repair any damage present within the sperm DNA.

Sperm are particularly vulnerable to oxidative stress and damage from reactive oxygen species (ROS). Excessive oxidative stress can impair mitochondrial function, reduce motility and increase DNA fragmentation.

Sperm health also influences much more than fertilisation. Research suggests that sperm quality affects placental development and may contribute to miscarriage risk. This is why supporting sperm health is just as important as supporting egg quality when preparing for pregnancy.

Mitochondria, Perimenopause and Menopause

Mitochondrial health isn’t only associated with fertility – these tiny structures may also influence when a woman transitions into perimenopause and menopause.

As women age, the number and function of mitochondria within the ovaries gradually decline. Research suggests that by age 40, approximately one-third of mitochondria within oocytes are no longer functioning efficiently.

Human oocytes contain between 100,000 and more than one million mitochondria because egg maturation and early embryonic development require vast amounts of energy. The rate at which these mitochondria decline appears to influence reproductive ageing.

Research published in 2024 demonstrated that reducing mitochondrial DNA accelerated reproductive ageing in animal models. This suggests that mitochondrial function may play an important role in determining the pace of ovarian ageing and potentially the timing of perimenopause and menopause.

This may help explain why many women notice changes in energy, recovery, metabolic health and stress resilience during the perimenopausal transition, however there is much more involved (if you’d like to learn more about perimenopause and menopause, go on the wait list for my upcoming book Natural Menopause Support).

Researchers have also identified CoQ10 as an important nutrient within ovarian tissue. One landmark study found that age-related declines in egg quality were partly driven by reduced CoQ10 availability within the oocyte. Supplementation helped preserve ovarian reserve, improve egg quality and restore fertility in aged mice. Additional research has also demonstrated improvements in progesterone production.

While ageing is a natural process, supporting mitochondrial health may help support healthier ovarian ageing and improve resilience during the transition into perimenopause and menopause.

Mitochondria and Endometriosis

While we’re on the topic of women’s health, it’s worth exploring the connection between mitochondria and endometriosis.

Many people think of endometriosis primarily as a hormonal condition, but there is also a significant immune and inflammatory component.

Women with endometriosis often experience increased oxidative stress, elevated inflammatory markers and altered immune function. Mitochondria are involved in all three of these processes.

When mitochondria become dysfunctional, they can produce excessive amounts of reactive oxygen species. This creates a cycle of oxidative stress and inflammation that may contribute to the growth and persistence of endometriosis lesions.

Mitochondria also play an important role in immune cell function and inflammatory signalling. When mitochondrial function is impaired, immune regulation can become disrupted, potentially contributing to the chronic inflammatory environment seen in endometriosis.

This is one reason why a holistic approach to endometriosis management often extends beyond hormones alone. Supporting mitochondrial health alongside nervous system regulation, immune function, gut health and hormonal balance may help address some of the underlying drivers involved in the condition.

Mitochondria, Mood and Brain Health

The brain is one of the most energy-demanding organs in the body.

Every thought, memory, movement and emotion requires energy. Healthy mitochondrial function helps support neurotransmitter production, nerve cell communication and overall brain function.

When mitochondrial function is impaired, symptoms such as brain fog, poor concentration, low mood and fatigue may occur.

Emerging research has also found that mitochondrial dysfunction is common in individuals with Autism Spectrum Disorder (ASD). Studies have identified abnormalities in mitochondrial energy production, increased oxidative stress and higher levels of neuroinflammation in some individuals with ASD.

Because mitochondria play such a central role in brain energy metabolism, supporting mitochondrial health may be an important consideration in conditions involving cognitive function, mood and neurological health.

Signs Your Mitochondria May Need Support

Some common signs that mitochondrial function may be struggling include:

• Persistent fatigue
• Poor exercise recovery
• Muscle weakness
• Brain fog
• Poor concentration
• Low mood
• Fertility challenges
• Hormonal imbalances
• Reduced resilience to stress
• Feeling older than your age

These symptoms can have many different causes, but mitochondrial dysfunction is one possible contributor worth considering.

Supporting Mitochondrial Health Naturally

Mitochondrial support is rarely about a single supplement. Instead, it involves creating an environment that allows these cellular powerhouses to function optimally.

Some of the ways mitochondrial health can be supported include:

• Prioritising quality sleep, as much of the body’s cellular repair occurs during sleep
• Maintaining stable blood sugar levels through a balanced diet
• Regular exercise, which stimulates the production of new mitochondria
• Spending time outdoors and supporting healthy circadian rhythms
• Cold exposure, which may help improve mitochondrial resilience and adaptation
• Supporting gut health and addressing dysbiosis where present
• Reducing exposure to environmental toxins where possible
• Ensuring adequate intake of nutrients required for mitochondrial function
• Supporting nervous system regulation and reducing chronic stress

Because mitochondrial health sits at the intersection of fertility, hormones, inflammation, energy production and healthy ageing, it can be a valuable area of focus in naturopathic care.

If you’re struggling with fertility challenges, subfertility, recurrent miscarriage, endometriosis, fatigue, hormone imbalances or perimenopausal symptoms, supporting mitochondrial health may be one piece of the puzzle worth exploring.

References

1. Annesley, S. J., & Fisher, P. R. (2019). Mitochondria in Health and Disease. Cells, 8(7), 680. https://doi.org/10.3390/cells8070680
2. Ben-Meir, A., Burstein, E., Borrego-Alvarez, A., Chong, J., Wong, E., Yavorska, T., Naranian, T., Chi, M., Wang, Y., Bentov, Y., Alexis, J., Meriano, J., Sung, H. K., Gasser, D. L., Moley, K. H., Hekimi, S., Casper, R. F., & Jurisicova, A. (2015). Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging. Aging cell, 14(5), 887–895. https://doi.org/10.1111/acel.12368
3. Ben-Meir, A., Kim, K., McQuaid, R., Esfandiari, N., Bentov, Y., Casper, R. F., & Jurisicova, A. (2019). Co-Enzyme Q10 Supplementation Rescues Cumulus Cells Dysfunction in a Maternal Aging Model. Antioxidants (Basel, Switzerland), 8(3), 58. https://doi.org/10.3390/antiox8030058
4. Chiang, J. L., Shukla, P., Pagidas, K., Ahmed, N. S., Karri, S., Gunn, D. D., Hurd, W. W., & Singh, K. K. (2020). Mitochondria in Ovarian Aging and Reproductive Longevity. Ageing research reviews, 63, 101168. https://doi.org/10.1016/j.arr.2020.101168
5. Khaliulin, I., Hamoudi, W., & Amal, H. (2025). The multifaceted role of mitochondria in autism spectrum disorder. Molecular psychiatry, 30(2), 629–650. https://doi.org/10.1038/s41380-024-02725-z
6. Kobayashi, H., & Imanaka, S. (2024). Mitochondrial DNA Damage and Its Repair Mechanisms in Aging Oocytes. International journal of molecular sciences, 25(23), 13144. https://doi.org/10.3390/ijms252313144
7. Kramer, P., & Bressan, P. (2018). Our (Mother’s) Mitochondria and Our Mind. Perspectives on psychological science : a journal of the Association for Psychological Science, 13(1), 88–100. https://doi.org/10.1177/1745691617718356
8. Long, S., Zheng, Y., Deng, X., Guo, J., Xu, Z., Scharffetter-Kochanek, K., Dou, Y., & Jiang, M. (2024). Maintaining mitochondrial DNA copy number mitigates ROS-induced oocyte decline and female reproductive aging. Communications biology, 7(1), 1229. https://doi.org/10.1038/s42003-024-06888-x
9. Melhuish Beaupre, L. M., Brown, G. M., Braganza, N. A., Kennedy, J. L., & Gonçalves, V. F. (2022). Mitochondria’s role in sleep: Novel insights from sleep deprivation and restriction studies. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 23(1), 1–13. https://doi.org/10.1080/15622975.2021.1907723
10. Tesarik, J., & Mendoza-Tesarik, R. (2023). Mitochondria in Human Fertility and Infertility. International journal of molecular sciences, 24(10), 8950. https://doi.org/10.3390/ijms24108950
11. May-Panloup, P., Boucret, L., Chao de la Barca, J. M., Desquiret-Dumas, V., Ferré-L’Hotellier, V., Morinière, C., Descamps, P., Procaccio, V., & Reynier, P. (2016). Ovarian ageing: the role of mitochondria in oocytes and follicles. Human reproduction update, 22(6), 725–743. https://doi.org/10.1093/humupd/dmw028
12. Vaught, R. C., & Dowling, D. K. (2018). Maternal inheritance of mitochondria: implications for male fertility?. Reproduction (Cambridge, England), 155(4), R159–R168. https://doi.org/10.1530/REP-17-0600
13. Wen, Y., & Yao, Y. (2021). Autism Spectrum Disorders: The Mitochondria Connection. In A. M. Grabrucker (Ed.), Autism Spectrum Disorders. Exon Publications. https://doi.org/10.36255/exonpublications.autismspectrumdisorders.2021.mitochondria

The post Mitochondria and Fertility: Egg Quality, Endometriosis, Menopause and Healthy Ageing appeared first on Alison Mitchell Naturopath.

Health & Wellbeing Podcast #32

Medicinal Mushrooms are growing in popularity all over the world, and not without reason. Medicinal and functional mushrooms are showing a huge amount of promise when it comes to improving our health and wellbeing. You might have heard of some of the more common mushrooms like Shiitake and Reishi mushroom, but there’s a whole heap of mushrooms with different benefits.

I was privileged to have a mushroom expert on the podcast – Jeff Chilton, founder of one of the leading medicine mushroom companies, Nammex.

Jeff is a wealth of knowledge and is very passionate about quality of mushroom supplements, something which we talked a lot about in this podcast. On top of that, he’s also a very lovely man, and patiently waited while I had to look after baby Lara a few times in the podcast, or while airplanes flew over (it was a noisy day then it seems!).

We spoke about the different properties of medicinal mushrooms, why it’s important to grow medicinal mushrooms organically, some of the quality issues that we face in choosing medicinal mushroom supplements, and Jeff shares a trick that we can do at home to tell if our mushroom supplements are quality or not.

Did you Know – Your Mushroom Supplements could contain grains.

Did you know that there are many types of mushroom supplements sold that contain grain? In a cost saving measure some companies will grow the mushrooms on grain. The mycelium (like the tiny roots of the mushroom) will spread throughout the grain and when it comes time to harvest, both the mycelium and the grain is taken. It’s virtually impossible to separate the grain from the mycelium, but not all companies are transparent with this. In some analysis it’s found that the chemical components of the supplements match the profile of the grain – so you’re essentially taking a glorified grain supplement.

Thankfully there’s an easy way to tell if your supplement contains grains – Jeff tells you how to do this in the podcast.

The Podcast

Click here to listen on Soundcloud, or via the embedded player below.

iPhone   Stitcher   Youtube   Soundcloud

Don’t forgot to leave me a 5* review on iTunes or on your podcast app.

Understanding Mushroom labels

Fruiting body refers to the part of the mushroom you see growing – usually that’s the cap and stem.

Mycelium is the cobweb like root structure that grows below the surface. This may be referred to on supplement labels as hyphae, mycelium or myceliated grain.

Another phrase that may be used is ‘full spectrum’, meaning that the mushroom contains both mycelium and fruiting body. To be truthful companies should detail the percentage of fruiting body contained in their supplements, and should not use the term full spectrum if the mushroom is grown on grain.

Benefits of Medicinal Mushrooms

Medicinal mushrooms have been used in traditional chinese medicine for centuries. There’s countless types of mushrooms used medicinally, but there are some select mushrooms which have been studied, and these are the more popular ones.

The benefits they show vary depending on the mushroom, and usually take a few days-weeks to achieve their effect.

There are so many types of medicinal mushrooms, but these are some of the more popular ones and their reported actions.

Shiitake

Lentinula edodes

• Immune tonic
• Anti-viral, anti-fungal, anti-bacterial
• Can be used in cooking
• Lowers blood cholesterol
• Lowers blood pressure
• Potential anti-cancer activity

Reishi

Ganoderma lucidum

• Immune tonic
• Adaptogen – helps the body cope with stress
• Calms the nervous system
• Supports good sleep
• Brain tonic
• Strengthens heart Qi
• Potential anti-cancer activity
• Can reduce allergies

Lion’s Mane

Hericium erinaceus

• Brain tonic
• Supports the nervous system, including nerve repair
• Supports stomach health and helps to heal stomach lining
• Anti-inflammatory
• Anti-microbial

Chaga

Inotus obliquus

• Anti-oxidant
• Immune modulator
• Balances blood sugar levels
• Supports pineal health
• Improves sleep
• Anti-viral
• Anti-fungal

Cordyceps

Cordyceps sinesis CS-4, Cordyceps militaris

• Adaptogen – improves the bodies ability to cope with stress and reduces fatigue
• Improves athletic performance
• Tonic for the new mothers
• Improves mental clarity
• Helps recovery after a big infection/illness
• Lung and cough tonic
• Sexual tonic

I find this mushroom so interesting I’m dedicating a whole blog post to it – I’ll add the link here when it’s up in a week.

Jeff’s links:

www.nammex.com

realmushrooms.com/

The post Medicinal Mushrooms appeared first on Alison Mitchell Naturopath.

The final part of my series for Western Sydney Mum’s Hub is about how to support your teenagers brain health in preparation for exams and tests, and supporting study in general.

The constant pressure of tests and exams on teenagers can make the whole family stressed, but thankfully there are some ways in which you can help your teenager boost their brain power, reduce anxiety and improve energy.

Click here to skip to the full article, or see a preview below.

The post Navigating the Teenage Years – Part 3 appeared first on Alison Mitchell Naturopath.

My latest contribution to Western Sydney Mums’ Hub is the first of a three parter, focused on teenage health.
A few years ago I held a talk about some ways to nourish your teenager through diet and how to navigate the tricky periods of these years such as puberty, exams and their changing brains. I have covered this topic again, and started off by talking about the teenage brain and the changes it goes through.

Photo by Zhivko Minkov on Unsplash

The Teenage Brain

Teenagers aren’t just smaller adults. Their brains are quite different in functioning and this keeps going until the 20s and 30s.
When entering puberty the brain goes through a rapid growth spurt which is very similar to what happens in small babies.

There is a growth spurt in the frontal cortex before puberty starts, with a thickening of the grey matter in this area. The grey matter of the brain is where the thinking and processing happens, and the white matter is where the transport of messages occurs.

The brain matures in a back to front pattern, with the frontal and temporal lobes being the last to mature. The frontal lobe is the home of planning, organisation, impulse control and reasoning.

These changes help to explain why teenagers have such a hard time regulating their mood swings. The hormonal changes can bring the mood swings on, but the changes in the brain mean that can’t regulate their behaviour, and are less likely to make more rational decisions.

Teens have a harder time analysing the emotions of others, and are more likely to perceive anger and threat in others, where there may not be. They are more likely to have a ‘gut reaction’ to these ‘threats’ as well.

In a study where teenagers were shown pictures of adults with various facial expressions, which adults would normally interpret as emotions of fear or concern were often interpreted by teens as shock and anger.

Pruning of the Brain

There is also a process that occurs that is essentially like ‘pruning’ or a use it or lose it process of certain cells and connections. Choosing which habits are practised more regularly in this time is important, because for most people opting for the academic, sport or music sort of pathways rather than the video gaming pathways. The adolescent brain is very versatile and can adapt to the environment very well.

Having an immature frontal cortex also means their ability to perceive risk and consequences is quite low. Not wearing helmets, performing more daring moves on their skateboard or even having unprotected sex and drug taking are examples of this. Teens usually feel that the risk is outweighed by the reward in these instances.

It’s not that teens are dumb by any means, in fact they are at a peak time for learning and processing and making new pathways in their brain. They can be amazing at solving puzzles, memorising things and learning new tasks like languages and music, but can have difficulty with analysing emotions and correctly assessing consequences of risks.

Mood swings

Apart from zits, one of the other more well known problems that teenagers can struggle with is mood swings.

Thinking about how their brain develops, it’s a bit easier to understand how teenagers have a much harder time processing their emotions as well as accurately perceiving the emotions of others.

In addition to that, teens are also going through a time where they’re trying to discover their place in the world. A lot of teenagers report feeling frustrated because they’re being told to act like adults, but they’re not getting treated like adults.

It’s a hard time for parents as well, because the way that you would have dealt with your younger child’s problems is quite different to the way you would deal with teenage problems, and a lot of the time you’re in a position where you are being pushed away and you don’t even know what they’re upset about.

Depression can affect teenagers, with 5% of teens experiencing depression to such a degree that it warrants treatment. Thankfully with the way the brain is continually reprogramming itself during the teenage years it can be very responsive to interventions.

If you suspect your teenager has depression, there are a few things you can do:

• You can try to talk to them. If they’re not forthcoming with a general discussion, try asking more specific questions related to those indicators of depression
• Encourage them to talk to someone they feel comfortable with
• Talk to your doctor
• Seek counselling
• Or See a qualified natural therapist

How to reduce mood swings:

There are a few ways that you can help to reduce the severity of mood swings, by reducing the fluctuations of hormones and blood sugar levels that impact on neurotransmitters and brain function.

• Eating a low GI diet will prevent blood sugar level fluctuations which can upset moods
• Eating a nutrient dense diet can help provide the brain with nutrients it needs for a calm mood. In particular, magnesium, zinc and B vitamins.
• Exercise can release endorphins which improve mood.
• Get 9 hours sleep a night, with a regular sleep routine.
• Employ stress management techniques such as mindfulness, journaling, exercise or meditation.
• If severe, consult a practitioner.

Tips for a Low GI, nutrient dense diet

Ensure there’s plenty of good fats such as coconut oil, butter, nuts and seeds, olive oil and avocado. Nut butter and almond butter are a great snack idea and really help to satisfy hunger.

Beans, legumes and brown rice are a cheap way to add in some extra fibre, complex carbs and calories. Have a side of these with your main meals, and make dips with beans for some extra sustenance throughout the day. To reduce the gas you can experience with them, use dried beans, soak them overnight then cook on the stove for a few hours, rather than buying the tinned. You can keep them in the fridge for about a week.

Aim for 2 to 3 pieces of fruit a day, and at least 5 serves of vegetables a day. Starchy veg like sweet potato, potatoes and pumpkin are a great source of calories and have plenty of fibre.

If you choose, you can use Meat, chicken and fish for additional protein.

Whether you choose to include grains and dairy in the diet depends on the individual, but if there’s no intolerance than yoghurt and cheese are a good addition, and melted cheese can help make a lot of veg more palatable for fussy teens.

READ PART 2 HERE

The post Surviving the Teenage Years – Part 1 appeared first on Alison Mitchell Naturopath.

Guest Post by New Image Personal Conditioning

I know training may not come as a natural love for everybody, however I know most of you would agree that the benefits of exercise flow on to other areas of your life, beyond the walls of New Image. Exercise can affect your life in such a positive way and the psychological benefits cannot be underestimated. Over the years I’ve seen many amazing clients go from lethargic, unmotivated and depressed to people who are motivated, full of life and with an attitude that could conquer any life hurdle. It is inspiring and the main reason I am in this industry.

Dr. Joanna McMillan (resident Dietician and Nutrition consultant for the Today show), states the benefits of exercise perfectly –

“Exercise changes the way your body works – for the better. It increases blood flow and delivery of nutrients around the body. It increases the effectiveness with which your body distributes oxygen and how well the heart can pump blood. It improves the functioning of your brain. It improves your mood (intense exercise is one of the best lifestyle changes you can make to reduce depression). It stimulates muscle growth and strength and muscles in turn get better at taking up glucose from the blood. Insulin sensitivity improves, reducing the risk of diabetes. You get better at burning fat for fuel. In short exercise makes your body work better. And the research clearly shows that if you want to lose weight and keep it off, you’d better make regular exercise a part of your life.”

Exercise and healthy eating are not at short term, ten week event. In order to change our daily habits and create new, more productive and healthy habits, eating healthy and regular exercise needs to become a staple for our lives. Initially the changes can be challenging, but many clients will attest to the life changing freedom that comes from feeling happy in your own skin, confident in your body’s ability to cope with daily activities and the little hint of pride that comes with knowing you have worked hard for every bit of your success. So keep at it! Don’t give up when it’s hard! Remember you are more than capable to achieve your results, you just need to be consistent!

New Image is a results driven private fitness studio located in Norwest Business Park.  Call or email to enquire about individualised exercise programs and professional advice in a fun, encouraging environment, where the only muscle and sweat will be yours.

Unit 216, 33, Lexington Drive, Norwest Business Park, Bella Vista NSW 2153
Phone: 8883 4031 Fax: 8883 4032
 www.newimagept.com.au  www.facebook.com/newimagept

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