A condition that is growing in awareness is Pyrolle disorder. This condition is associated with many types of problems but in particular mood imbalances, gut symptoms and behavioural issues in children. The diagnosis of conditions such as ADD/ADHD, food intolerances or anxiety may be related to Pyrolle disorder, so if you or someone you know has these health concerns, this might be something to look in to.

In my latest contribution to Western Sydney Mum’s Hub I talk about what Pyrolle disorder is, the symptoms you can look for as a clue, how to test for this condition and what you can do to help it with diet changes and herbal medicine.

Originally published here https://www.westernsydneymumshub.com.au/parenting/what-is-pyrolle-disorder.

So what is it?

Also referred to as pyroluria, mauve disorder or kryptopyrroluria, pyrolle disorder is a condition where there is an abnormal amount of the chemical hydroxyhermopyrrolin-2-one (HPL) excreted. Everyone produces this chemical in small amounts, however excretion of high levels may be linked to issues with the nervous system (usually resulting in mood and behavioural problems) and digestive complaints. When this occurs it is referred to as pyrolle disorder.

If you have ongoing issues with mental health, especially anxiety, this may be something to look into. It affects about 10% of the population and can be brought on by periods of stress, both emotional and physical, as stress causes the HPL chemical to be excreted very quickly.

It affects children and adults and can be a factor in various mental health issues, mostly anxiety, behavioural problems, ADHD, addictions and autism.

What are the Symptoms?

This condition can affect someone in a lot of different ways, mostly via the way it affects the nutrients zinc and B6 which are critical for health digestion, immune function, hormonal health and emotional balance. Not everyone experiences all the symptoms, but the expression of the condition could involve some or all of the following symptoms:

·         Anxiety

·         Depression

·         Mood swings

·         Low tolerance to stress

·         Sensitivity to noise and lights

·         A dramatic tendency (histrionic)

·         Pessimistic

·         Digestive complaints such as constipation or diarrhoea

·         Poor dream recall

·         White spots on nails

·         Poor appetite or nausea, especially mid morning

·         High tendency to stretch marks

·         Inability to tan or very pale skin

·         Skin complaints such as eczema, dry skin or rough skin on the back of the arms (keratosis pilaris)

·         Thinning hair and early greying of the hair

·         Sore joints

·         Irregular periods or delayed puberty

There can also be an allergy component to the condition as it affects histamine levels. I consider this helpful to test when supporting people with pyrolle disorder.

This condition has also been associated with other conditions such as autism , ADD/ADHD, allergies, alcoholism and additions, learning difficulties, epilepsy, schizophrenia, bi-polar disorder and acute intermittent porphyria.

How is it tested?

A urine test that measures the levels of pyrroles (hydroxyhaemopyrrolin-2-one i.e. HPL) in the urine can give you a big indication whether this condition is an issue for you.

Most people should have low levels – less than 10mcg/dL of HPL in their urine. The upper limit of normal for HPL varies between 8-20 mcg/dL and levels greater than 20 mcg/dL are considered to be positive for pyrrole disorder. While that may be a positive test for pyrolle disorder, in clinic I have found that until levels get even higher then pyrolle disorder isn’t the main cause for the symptoms experienced and shouldn’t be the key focus of treatment.

Is it genetic?

There is a high likelihood that it is a genetic condition, with a 50% chance that if one parent has the condition that it will be passed onto the child.

Other genes can have a role in this condition such as MTHFR.

A lot of the time this condition may not be an issue, but in combination with stress, trauma or dietary/lifestyle issues it can become a bigger problem.

How is it treated?

A holistic approach is important, as there are often a combination of factors involved.

Usually repletion of the nutrients zinc and Vitamin B6 are important, but other nutrients such as magnesium, omega fatty acids and supporting B vitamins are important.

As the condition affects, and is affected by digestive health, the gut also needs to be supported with diet, and gut supporting nutrients and probiotics.

Diet for Pyrolle Disorder

Top foods to find zinc and B6

Zinc containing foods: Spinach, prawns, oysters, salmon, flaxseeds, pumpkin seeds, cashews, mushrooms, garlic, lima beans, chickpeas, kidney beans, peas, eggs, turkey, beef, lamb, liver, brown rice.

B6 containing foods: Sunflower seeds, pistachios, salmon, turkey, lean pork, beef, prunes, banana, avocado, spinach, fortified cereals, rice bran.

Top foods for GLA (gamma-linolenic acid)

Avocado, brazil nuts, hemp seeds, peanuts, chicken liver, pinenuts, spirulina, borage oil.

Foods to avoid:

Those which are difficult to digest and are classed as inflammatory. This often includes gluten, dairy, alcohol, heavily processed or sugar rich foods and anything that contains chemicals or is overly refined. Some people respond best to a paleo style diet, or one free from grains.

Herbal medicine for Pyrolle Disorder

The symptoms of the condition vary for everyone, and so herbal medicine can be targeted to this. It may involve using herbs to support concentration and memory such as Bacopa, digestive health such as Gentian, Ginger, Dandelion root, Chamomile and Lemon Balm, or to reduce anxiety such as Passionflower. A herbalist can individualise a formula to the person.

If you think this may be an issue for you, seek help from a qualified health practitioner with experience in this area.

The post What is Pyrolle Disorder? appeared first on Alison Mitchell Naturopath.

When your gut controls your mood: the gut-brain axis

From as early as the 1930’s, scientists were beginning to understand that the health of our digestive system could influence our mood.  The state of our intestinal lining and the balance of bacteria within our digestive system have a major role to play in the production of our neurotransmitters: chemical transmitters that tell our brain whether we should be feeling such ways as happy, sad, agitated, or calm.  But even though the research in this area sky-rocketed in the last decade and continues to grow every day, the concept of our gut-brain connection isn’t very well known.

The gut is linked to the brain

Did you know – When you were just starting to grow in your Mumma’s womb, your brain and your digestive system developed from the same lump of tissue.  During this process of dividing up cells (embryogenesis) this lump of tissue divides and forms our central nervous system and our enteric nervous system (this is the nervous system of our gut – sometimes called the second brain).  These two are connected by an important ‘wire’ – our vagus nerve.  This development can help us understand why there are so many similar chemicals and receptors in both our brain and our digestive system, for instance serotonin.

Gut bugs and your mood

As soon as you’re born, bacterial colonies start to develop in your digestive system.  Within the first few days, the bacteria starts sending messages to the nervous system and can actually determine our nervous system ‘set point’ long term (1).

When the balance of our gut bacteria (collectively referred to as the microbiome) is affected, this can affect your mood.  Studies have found that the microbiome can have a major impact on stress levels and anxiety (2).  In fact, by treating imbalances in our microbiota, it is possible to support a wide range of mental health disorders (3), (4), (5), (6), (7).

The second brain

The nerves in your digestive system are constantly speaking to your central nervous system.  If your gut is irritated for some reason – say you’ve eaten something that you’re intolerant to (like gluten, for example), you’ve generally got a bad diet, there’s an imbalance in your microbiome (that’s your collective gut bacteria, remember) or you’ve got an infection – this can create an inflammatory reaction and will certainly make you irritated as well.  We know that depression is both associated with, and worsened by inflammation.  This inflammation in the brain can be driven by inflammation in the gut, which can be caused by intestinal permeability (leaky gut) and bacterial imbalances (dysbiosis).  Treating leaky gut can help reduce the severity of depression (4), (8), (9), (10), (11).

Neurotransmitters in our gut

Serotonin is produced in large amounts in our digestive system.  In people with Irritable Bowel Syndrome (IBS) there is too much serotonin in their digestive system.  This is why antidepressants known as SSRI (selective serotonin reuptake inhibitors) can improve the symptoms of IBS: these act by reducing the amount of serotonin taken into cells in the rest of our body which allows more to get into the brain.  However anti-depressants can affect the gut negatively as well, because if you weren’t making enough serotonin in the gut in the first place, you’d end up with even lower levels in the digestive tract and so it can become irritated, affectively you’ll get a depressed gut (12), (13).

A vicious cycle

When your gut is upset, you feel upset.  But stress can affect your digestive system just as much as it affects your mood.  It can impair the secretion of digestive acids, slow down the motility of the gut, allows the unfriendly bacteria to grow, reduces your friendly bacteria and exacerbates intestinal permeability (leaky gut) (14), (8).  This is a recipe for an unhappy digestive system, and as you know this can then go on to send more messages to your brain: so you can see how the cycle continues.

People with gut problems are more likely to experience anxiety and depression.  Some studies have found a high proportion of anxiety in those with gut conditions such as Irritable Bowel Syndrome(IBS), Crohn’s disease and coeliac disease (15), (16), (17).

Helping the gut-brain axis.

By treating digestive problems, sealing leaky gut and balancing your microbiome it is possible to help with conditions such as anxiety and depression, and there’s even research showing the benefits of treating the gut in conditions like chronic fatigue syndrome, schizophrenia and autism (10), (18), (11).  Probiotics are one of your major tools when it comes to treating the gut, but it’s a good idea to consult with a health practitioner to make sure you’re getting the right type, and also to get a good gut healing treatment program to go along with it ⁽¹⁹⁾, (4), (9).

Related articles:

• Probiotic stress busters: http://www.naturopathnsw.com.au/probiotic-stress-busters
• Depression starts in the gut?:  http://www.naturopathnsw.com.au/depression-begins-in-the-gut
• What is Dysbiosis: http://www.naturopathnsw.com.au/what-is-dysbiosis
• Fermented foods (foods to stop bloating and farting): http://www.naturopathnsw.com.au/foods-to-stop-bloating-and-farting-fermented-foods
• Enhance your health with probiotics: http://www.naturopathnsw.com.au/enhance-your-health-with-probiotics
• The benefits of soaking and sprouting: http://www.naturopathnsw.com.au/the-benefits-of-soaking-and-sprouting-plus-a-sprouted-chickpea-hummus-recipe

Works Cited

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